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Lorre is the brains behind evil Wil Wheaton, but it was fan Prady who had to make the call and break the news to the actor. During a scene when Howard (Simon Helberg) has a dream about Katee Sackhoff, producers toyed with the idea of having George Takei do some voice work.

"I didn't know this guy, and I had to call him and say, ' So you're playing yourself ... "We wrote a line of Howard saying, ' I'm so confused,' and thought it'd be really funny if George Takei said, ' Confused? "How do I say to this guy that he's a possible homosexual fantasy?

" and who had a major problem with the Smurf makeup?

The addition of Melissa Rauch and Mayim Bialik in later seasons also enhanced the stories and relationships of the leads.It took only one take for Cuoco and Galecki to film Penny professing her love for Leonard. Wolowitz voice -- which again was present, as it is every year at Comic-Con -- isn't the only impression Melissa does on the show. "It's lovely to see him get to explore that side to himself, which has been amiss for so long," he said."Kaley said to Johnny, ' I don't know about you, but when we started the scene, the cameras and the live audience all went away and it was just us,' " new showrunner Steve Molaro recalled, noting that he told both actors the shot was beautiful and he knew they'd never get anything better. Turns out Bernadette's actual voice is based on her mother. "We can joke and laugh, but ultimately for him he really wants this.When Sheldon punishes Amy (Mayim Bialik) with a spanking for faking illness in order to enjoy the ointment rub, it wasn't in the original script and was supposed to be off-screen.Parsons shared that there were three jokes -- a "hear no evil, see no evil, speak no evil" string of monkey scenes -- that ultimately were trimmed from the script one by one.

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